Introductions

Hello!

I am Brad Bloomfield, and I am a lecturer in Applied Behaviour Analysis (ABA) at Monash University and I’m based in Melbourne, Australia.

1. What N-of-1 and single-case projects are you working on right now?

I’m interested in the use of telehealth to support families and schools gain skills in behaviour support strategies. I am currently working on a teacher training study on classroom management strategies and parent training in paediatric feeding intervention study.

2. What excites you most about the field of N-of-1 trials and single-case designs?

I really like how direct the impact of the intervention can show changes in observed behaviour in a socially significant way. There is a lot of flexibility within these designs that support individualised systems of supports.

3. Why did you join the ICN?

I enjoy using single case research design in my program of research and also teach this to the students in the course I teach. I am really interested to expand my understanding of single-case research outside the field of ABA and build connections with other scholars and practitioners in the field.

Hello!

My name is Shamima Banu and I am currently studying medicine at The University of Queensland in Brisbane, Australia.

1. What N-of-1 and single-case projects are you working on right now?

My exposure to N-of-1 studies was made possible by Dr Nikles and Dr McDonald since 2018. I have been working on N-of-1 studies relating to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and other systematic reviews involving N-of-1 studies.

2. What excites you most about the field of N-of-1 trials and single-case designs?

The translational capacity of this field into clinical medicine, especially personalised medicine to individual patients is what that excites me the most on working in the field.

3. Why did you join the ICN?

I decided to join the ICN to expand my involvement and knowledge on the field of N-of-1 trials and single-case designs. I hope to learn more about this methodology and it's use in clinical medicine.

Greetings! I'm Eric J. Daza, a digital health data scientist at Evidation Health based out of the San Francisco Bay Area, CA, USA. 1. What N-of-1 and single-case projects are you working on right now? Stats-of-1! It's a blog for per-individual study design and analysis methods, that is lay-oriented and interdisciplinary. Our mission is to facilitate cross-disciplinary collaboration that will enhance idiographic data collection and analysis procedures across health disciplines. We call this statistical field esametry.

2. What excites you most about the field of N-of-1 trials and single-case designs?

The sheer potential for n-of-1/single-case methods to innovate and advance digital health applications, and vice-versa.

3. Why did you join the ICN? I was graciously invited by Drs. Nikles and McDonald to join sometime in 2016-2017. Very grateful they reached out to me! The ICN is a great resource for building community around our common interests.

Hi!

My name is Rachael Dodds and I am currently studying medicine at the University of Queensland in Brisbane, Australia.

1. What N-of-1 and single-case projects are you working on right now?

I was introduced to N-of-1 projects when I completed some volunteer research last year. I'm not currently working on any N-of-1 projects.

2. What excites you most about the field of N-of-1 trials and single-case designs?

How widely applicable they are, especially in medicine and healthcare!

3. Why did you join the ICN?

I decided to join the ICN as I've become interested in N-of-1 projects and wanted to be more involved in spreading awareness about these trials in addition to learning more about the field.

Hi!

My name is Patrick Onghena, and I am currently working at the Faculty of Psychology and Educational Sciences, KU Leuven, Belgium.

1. What N-of-1 and single-case projects are you working on right now?

I'm involved in several applied and methodological single-case projects. The applied projects include a personalized intensive exposure-based intervention targeting persistent anxiety and (imminent) school absenteeism in youth and a project on behavioral parent training for children with attention-deficit/hyperactivity disorder. The major methodological projects are software development for comprehensive single case data analysis and the development of mixed methods single case research.

2. What excites you most about the field of N-of-1 trials and single-case designs?

I was trained as a clinical psychologist and psychotherapist and it always struck me how much can be learned about "human nature" (and its diversity) by intensively talking, listening, and working with an individual person. Psychotherapy is in a way a discovery of personal patterns, recurrences, and individual laws of behaviors, thoughts, words, and feelings, before trying to incite changes. So when I started with my PhD research about the effectiveness of psychotherapy more than 30 years ago, I really wanted to keep that focus on the individual. SCEDs seemed the ideal method to evaluate effectiveness and keep that focus, and I still think it is. After 30 years, it still excites me to explain to my colleagues the painfully obvious that a between-subjects effect is fundamentally different from a within-subject effect. It is fundamentally different for the science of psychology and it is fundamentally different for the person (and his family and friends) who is experiencing the effect.

3. Why did you join the ICN?

I think there is a need for more community building around N-of-1 and SCEDs. N-of-1 and SCED researchers are still a very small minority. And minorities need support. Even if one is a single-case researcher, it shouldn't imply that one is a lonely researcher.

Hi!

I am Cheuk Ka, currently program manager at an immuno oncology biotech in Singapore.

1. What N-of-1 and single-case projects are you working on right now?

I am not currently working on any N-of-1 projects.

2. What excites you most about the field of N-of-1 trials and single-case designs?

I am very intrigued by the potential of N-of-1 trials in furthering precision medicine, and in helping patients to find suitable treatments more efficiently.

3. Why did you join the ICN?

I am curious to know if there is a database of all N-of-1 studies conducted around the world, as a resource for patients/physicians looking for alternatives when standard of care treatments do not work.

Hi!

My name is Nikola Poli and I am currently working at the Queensland University of Technology in Brisbane, Australia. I have a Bachelor of Mathematics (Statistics), and will soon be moving overseas to study my Master of Science.

1. What N-of-1 and single-case projects are you working on right now?

Currently, I am conducting the statistical analysis for two N-of-1 studies: Melatonin in Youth: N-of-1 trials in a stimulant-treated ADHD Population (MYNAP) and N-of-1 Trials for Testing Melatonin for Insomnia for people with Parkinson's Disease. This is a great experience for me as recent graduate, as I have the opportunity to put my learnings from university into practice.

2. What excites you most about the field of N-of-1 trials and single-case designs?

The scope in the field! There is so much potential for N-of-1 trials and single-case designs to be widely used in our world, particularly in healthcare where we can use them to improve health outcomes. This makes it an exciting area for me as a young professional to be involved in.

3. Why did you join the ICN?

I joined the ICN because I am very interested in data analytics methods in medicine, particularly those used in N-of-1 trials and single-case studies. I have since joined the ICN Executive Committee as an Early Career Rep. In this role I hope to help the ICN's vision of increasing awareness of these methods with a particular focus on encouraging other young professionals to get involved in this field.

Hi all,

I'm Suzanne McDonald and I work as an N-of-1 clinical trial coordinator at The University of Queensland in Brisbane, Australia.

1. What N-of-1 and single-case projects are you working on right now?

I am currently running a programme of research called 'Making it Personal', which explores symptom patterns and triggers in chronic diseases using insights from N-of-1 observational studies. In addition, I am leading a project that explores stakeholder perspectives on N-of-1 trials and single-case studies. I am also working on the N-of-1 trial of Melatonin for insomnia in Parkinson's disease led by Jane Nikles.

2. What excites you most about the field of N-of-1 trials and single-case designs?

The vast opportunities that digital technology will offer the field of N-of-1 trials and single-case studies and the recent emergence of several robust statistical methods for analysing data. I am also excited by the prospect of using data from N-of-1 observational studies to inform the development and optimisation of highly personalised interventions.

3. Why did you join the ICN?

I have been co-chair of the ICN with Jane Nikles since 2018 and it has quickly grown into the largest network of its kind. I look forward to seeing what the future holds for the ICN and the impact it can make on the health outcomes of individuals and populations through advancing the science of N-of-1 trials and single-case designs.

Hi everyone

I am Jane Nikles, and I am currently working at The University of Queensland in Brisbane, Australia.

1. What N-of-1 and single-case projects are you working on right now?

We are currently finalising the data analysis for two N-of-1 studies: Melatonin in Youth: N-of-1 trials in a stimulant-treated ADHD Population (MYNAP) and N-of-1 Trials for Testing Melatonin for Insomnia for people with Parkinson's Disease.

2. What excites you most about the field of N-of-1 trials and single-case designs?

Their flexibility and adaptability to so many different contexts, and the fact that they fit so well within the trends of personalised medicine, consumer-centric healthcare and digital health.

3. Why did you join the ICN?

I felt it was important to form a community where we can share ideas and learn from each other. We have come a long way since those early days, and I am so proud to be part of this amazing network!